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Robert M W de Waal Selected Research

Familial Cerebral Amyloid Angiopathy

4/2010Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Abeta40 (DAbeta(1-40)) are modulated by sulfate moieties of heparin.
2/2010Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death.
2/2009Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion.
12/2007Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells.
2/2006Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity.
1/2004Insulin inhibits amyloid beta-induced cell death in cultured human brain pericytes.
10/2002Inhibition of amyloid-beta-induced cell death in human brain pericytes in vitro.

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Robert M W de Waal Research Topics

Disease

19Alzheimer Disease (Alzheimer's Disease)
01/2017 - 07/2002
15Cerebral Amyloid Angiopathy (Congophilic Angiopathy)
01/2017 - 10/2002
12Neoplasms (Cancer)
11/2008 - 01/2002
9Amyloid Plaque
01/2010 - 07/2002
7Familial Cerebral Amyloid Angiopathy
04/2010 - 10/2002
7Melanoma (Melanoma, Malignant)
06/2006 - 12/2002
6Neoplasm Metastasis (Metastasis)
02/2005 - 01/2002
2Synucleinopathies
10/2011 - 10/2004
2Uveal melanoma
09/2005 - 05/2003
2Colorectal Neoplasms (Colorectal Cancer)
02/2005 - 02/2005
1Parkinson Disease (Parkinson's Disease)
10/2004
1Dementia (Dementias)
10/2004
1Experimental Melanoma
07/2003
1Brain Neoplasms (Brain Tumor)
07/2003
1Arthrogryposis renal dysfunction cholestasis syndrome
05/2003
1Renal Cell Carcinoma (Grawitz Tumor)
12/2002
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
12/2002

Drug/Important Bio-Agent (IBA)

13Amyloid beta-PeptidesIBA
10/2010 - 07/2002
6Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA
04/2010 - 07/2002
5Amyloid (Amyloid Fibrils)IBA
01/2017 - 10/2002
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2003 - 01/2002
3Peptides (Polypeptides)IBA
04/2010 - 05/2003
3Proteins (Proteins, Gene)FDA Link
01/2010 - 09/2005
3Small Heat-Shock ProteinsIBA
02/2009 - 02/2006
3AngiostatinsIBA
06/2006 - 11/2004
2GlycosaminoglycansIBA
04/2010 - 10/2004
2ApolipoproteinsIBA
01/2010 - 04/2005
1SynucleinsIBA
10/2011
1Enoxaparin (Lovenox)FDA LinkGeneric
10/2010
1Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA
10/2010
1Heparitin Sulfate (Heparan Sulfate)IBA
02/2010
1Complement System Proteins (Complement)IBA
01/2010
1Interleukin-6 (Interleukin 6)IBA
02/2009
1Dexamethasone (Maxidex)FDA LinkGeneric
02/2009
1Molecular Chaperones (Chaperone, Molecular)IBA
02/2009
1Angiogenesis InhibitorsIBA
11/2008
1LDL Receptors (LDL Receptor)IBA
12/2007
1Receptor for Advanced Glycation End ProductsIBA
12/2007
1Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA
12/2007
1Heat-Shock Proteins (Heat-Shock Protein)IBA
06/2007
1Protein AggregatesIBA
06/2007
1tau Proteins (tau Protein)IBA
06/2007
1Caspase 3 (Caspase-3)IBA
09/2006
1Penicillamine (Cuprimine)FDA Link
06/2006
1Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA
02/2006
1AntibodiesIBA
09/2005
1plexinIBA
09/2005
1Single-Domain AntibodiesIBA
09/2005
1Bovine Serum AlbuminIBA
09/2005
1DNA (Deoxyribonucleic Acid)IBA
09/2005
1Dextrans (Dextran)FDA Link
09/2005
1Insulin (Novolin)FDA Link
09/2005
1CollagenIBA
09/2005
1Fluorescent Dyes (Fluorescent Probes)IBA
09/2005
1Apolipoproteins E (ApoE)IBA
04/2005
1P-SelectinIBA
02/2005
1EndostatinsIBA
02/2005
1Explosive Agents (Explosives)IBA
11/2004
1Plasminogen Activators (Plasminogen Activator)IBA
11/2004
1Captopril (Capoten)FDA LinkGeneric
11/2004
1PlasminogenIBA
11/2004
1alpha-SynucleinIBA
10/2004
1Amyloidogenic ProteinsIBA
10/2003
1Protein Isoforms (Isoforms)IBA
09/2003
1Proteoglycans (Proteoglycan)IBA
08/2003
1ferumoxtran-10 (ultrasmall superparamagnetic iron oxide)IBA
07/2003
1ferric oxide (iron oxide)IBA
07/2003
1Gadolinium DTPA (Magnevist)FDA Link
07/2003
1Contrast MediaIBA
07/2003
1ChemokinesIBA
05/2003
1Periodic AcidIBA
05/2003
1member 1 small inducible cytokine subfamily EIBA
05/2003
1Vascular Endothelial Growth Factor CIBA
05/2003
1Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA
12/2002
1CytokinesIBA
11/2002
1Insulin-Like PeptidesIBA
11/2002
1Leukemia Inhibitory FactorIBA
11/2002
1Insulin-Like Growth Factor Binding Protein 3IBA
11/2002
1Superoxide DismutaseIBA
10/2002
16- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA
10/2002
1Glutathione (Reduced Glutathione)IBA
10/2002
1CatalaseIBA
10/2002
1Vitamin EFDA LinkGeneric
10/2002
1EpitopesIBA
10/2002
1Collagen Type XVIII (Type XVIII Collagen)IBA
10/2002

Therapy/Procedure

4Therapeutics
06/2006 - 10/2002
1Drug Therapy (Chemotherapy)
11/2008
1Injections
09/2005